• Torment Difficulty:
Unique items have better drop chances in higher Torment difficulties.
• Farm Boss Hoards:
Ophidian Iris is listed from bosses such as Echo of Duriel, Echo of Andariel, and Harbinger of Hatred.
• World Drops:
Ophidian Iris can also drop from enemies, chests, World Events, Nightmare Dungeons, and other high-level loot sources.
• Helltide Chests:
You can farm Helltide events and open chests for additional chances at Unique item drops.
• Purveyor of Curiosity:
You can gamble for amulets with Murmuring Obols, but this is not the most reliable way to target-farm Ophidian Iris.